A new research review has shed new light on the negative impact that temporal lobe epilepsy can have on a patient’s capacity for emotional recognition. The University of Modena e Reggio Emilia study searched a number of medical databases from 1990 to March 2015 to identify papers relevant to this topic, with 996 citations identified and 43 studies finally included. read more
Below are the most recent news stories about epilepsy from Epilepsy Research UK and from around the world. You can choose different categories from the side bar on the left (for details of grants made prior to 2012, please visit our research portfolio). You can also catch up with Epilepsy Research UK's fundraising and research news in our supporter newsletters.
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Grant winner 2015 “This research will investigate the mechanisms by which seizures spread across the brain. If we can understand how the seizures spread we will be in a far better position to develop novel treatments to reduce or even prevent the spread of seizure activity.” Dr Jason Berwick (pictured) Grant type: Project grant Principal investigator: Dr Jason Berwick Institution: University read more
Grant winner 2015 “This study will give us a much better understanding of the risk factors for epilepsy-related death. We also hope that it will highlight changes in epilepsy in care that might help to avoid some of these deaths.” Dr Susan Duncan (pictured) Grant type: Project grant Principal investigator: Dr Susan Duncan Institution: Western General Hospital Edinburgh & Muir Maxwell Epilepsy read more
Grant winner 2015 “Drug-resistant focal epilepsies are notoriously difficult to manage, and they impact enormously on the lives of those of affected. Hopefully this technique will provide a new treatment option that will help to improve people’s quality of life and reduce epilepsy-related injuries.” Dr Gonzalo Alarcon (pictured) Grant type: Project grant Principal investigator: Dr Gonzalo Alarcon Institution: King’s College London Amount: £140,107 read more
Grant winner 2015 “We want to understand why someone might develop epilepsy after suffering a head injury, such as stroke, infection or head trauma. These are major causes of epilepsy and, currently, we just don’t know why or how this happens (and so we have no way of preventing it). This project will provide crucial insights into how epilepsy can develop, read more
Grant winner 2015 “The misdiagnosis of epilepsy remains a significant clinical problem, which can lead to delayed or unnecessary treatment. Our computer-based tool offers real potential to bring personalised medicine into epilepsy, which will ensure that people presenting at clinic receive an effective diagnosis and rapid access to the most appropriate treatment.” Professor John Terry (pictured) Grant type: Project grant Principal Investigator: Professor read more
Grant winner 2015 “This research will not only increase our understanding of epilepsy, but synaptic vesicles could prove a much-needed target for the development of new epilepsy drugs.” Dr Vincenzo Marra (pictured) Grant type: Pilot grant in epilepsy Principal investigator: Dr Vincenzo Marra Institution: University of Leicester Amount: £29,996 Duration: 8 months Scientific title: Alterations in vesicular dynamics at excitatory and inhibitory synapses in read more
Grant winner 2015 “Predicting which children are at greater risk for memory deficits after epilepsy surgery is still a significant clinical challenge. Our study will address this problem by designing and validating a developmentally appropriate brain imaging test.” Professor Stefano Seri (pictured) Grant type: Pilot grant in epilepsy Principal investigator: Professor Stefano Seri Institution: Aston University Amount: £21,666 Duration: 24 months Scientific title: Identifying developmentally-appropriate non-invasive functional read more
Grant winner 2015 “This pilot study will help facilitate larger studies into the mechanisms of depression in epilepsy, which could ultimately contribute to the development of further treatment strategies.” Dr Jacqueline Foong (pictured) Grant type: Pilot grant in epilepsy Principal investigator: Dr Jacqueline Foong Institution: University College London Amount: £29,977 Duration: 6 months Scientific title: Pathophysiological mechanisms of interictal depression in temporal lobe epilepsy Why is this read more
Grant winner 2015 “This research will enable us to maximise the use of living human tissue acquired through epilepsy surgery, which will in turn accelerate the gathering of information about drug-resistant epilepsies. Ultimately it will hopefully lead to the development of more effective drug treatments.” Professor Roland Jones (pictured) Grant type: Pilot grant in epilepsy Principal investigator: Professor Roland Jones Institution: University read more
A new study from Canada has indicated that children who undergo resective epilepsy surgery have a higher chance of experiencing academic difficulties thereafter. The University of Toronto Mississauga research examined the academic outcomes of a cohort of children who underwent paediatric epilepsy surgery for an average of 1.2 years after their procedure. To date, there have been few studies examining read more
A new study has highlighted the common issue of social cognition problems in patients with epilepsy, while calling for more attention to be paid to the matter. Led by Italy’s University of Palermo, the research sought to investigate social cognition abilities in patients with temporal lobe epilepsy (TLE) and idiopathic generalised epilepsy (IGE), with the aim of determining how these read more
For National Epilepsy Week, Sunday 17 May to Saturday 23 May, we’ve continued with our theme of ‘Transforming Lives Through Research’. We firmly believe that it is only through continued and increasing investment in research that we will see real benefits to those living with epilepsy. Our activities for National Epilepsy Week have included: a reception at the Royal Society read more
A new study has highlighted the benefits of using theory of mind assessments as a means of evaluating social functioning in people with temporal lobe epilepsy.
People with epilepsy are more likely to experience sleep disruptions if they are affected by depression, according to a new study. The Medical University of Vienna research, published in the medical journal Epilepsy & Behavior, aimed to assess the subjective quality of sleep and influencing factors on sleep quality in patients with partial epilepsy. A total of 32 epilepsy patients read more
A new study has demonstrated the equivalent results that oral and intravenous formulations of carbamazepine can offer for epilepsy patients. The phase I open-label study saw adult patients with epilepsy on a stable oral carbamazepine dosage converted to intravenous carbamazepine for a 28-day outpatient period, followed by an up to ten-day inpatient period and a 30-day follow-up. A total of read more
A new study has demonstrated the potential benefits of a potentially promising hybrid corticosteroid treatment regimen for patients with refractory childhood seizures. The team from the Erasmus University Hospital-Sophia Children’s Hospital in the Netherlands aimed to determine whether a pulse of corticosteroids could effectively reduce seizures, while using a low-dosage maintenance treatment to reduce side effects. A total of 26 read more
A new study from the US has demonstrated the effectiveness of the drug clobazam as an add-on therapy for refractory status epilepticus (RSE). Over a 24-month period, the study involved 17 patients with RSE who were treated with clobazam at Detroit Medical Center, with clobazam introduced after a median duration of four days and three failed antiepileptic drugs. According to read more
A new study has indicated that epilepsy can play a role in reducing the generation of neurons – a process that could be targeted in future treatment efforts.
A new study has indicated that exercise bikes can be useful tools in the treatment offered by epilepsy monitoring units (EMUs), assuming the proper safety controls are implemented. Long-term video electroencephalogram monitoring is a vital technique for EMUs, using exercise methods to trigger seizures that can then be analysed. This new study aimed find out if exercise bikes can be read more