The immune system may play a previously unknown role in the development of chronic epilepsy and other conditions following a brain injury. A team from the Cleveland Clinic have identified a role for a protein known as S100B – which serves as a biomarker for brain damage – in the onset of memory impairment and cognitive dysfunction associated with conditions read more
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Ketogenic dietary therapies could be a feasible and effective means of treating epilepsy in adult patients. Currently, ketogenic diets are recognised as an effective treatment for children with drug-resistant epilepsy, but there is no high-quality evidence supporting their use in adults, prompting this new study from the UCL Institute of Neurology. Published in the journal Epilepsy & Behavior, the study read more
A new therapy for epilepsy patients with partial-onset seizures has demonstrated its safety and efficacy in a phase III clinical trial. The study evaluated the drug brivaracetam as an adjunctive treatment in adult focal epilepsy patients with partial-onset seizures that are not fully controlled, despite treatment with one or two concomitant antiepileptic drugs (AEDs). Results from the trial revealed that read more
A new US study has identified a potential genetic link between epilepsy and neurodegenerative disorders.
The mechanisms behind seizure activity are extremely complex and researchers are still trying to unravel them. The scientific journal Nature has recently published a summary of important findings, and this includes a lot of Epilepsy Research UK-funded work (by Professor Matthew Walker and colleagues, at University College London, and Dr Andrew Trevelyan (former Epilepsy Research UK Fellow), at Newcastle University). Nature is a very well respected read more
Exercise programmes can deliver benefits for children with benign epilepsy, according to a pilot study.
Coexisting psychiatric disorders can make it less likely that patients with a certain form of childhood epilepsy will respond effectively to treatment with valproic acid (VPA). Conducted by the Krishna Institute of Medical Sciences In Hyderabad, a retrospective analysis of data from 201 patients with JME who had at least three years of follow-up has been performed in order to read more
A new study has demonstrated the benefits that adrenocorticotropic hormone (ACTH) therapy can bring for patients affected by late-onset spasms (LOS). Categorised as epileptic spasms that begin after the first year of life, LOS is a condition that generally has poor prognoses, with no established treatment strategy in place. However, this new study indicates that ACTH could be a promising read more
A new study has shown that temporal lobe epilepsy can have an impact on a patient’s ability to process and perform music.
A Harvard University research project has led to the development of a new way of observing and monitoring neural activity, which could facilitate the treatment of epilepsy.
Scientists in the US have revealed new insights into variations in neuronal networks that explain why people experience variable outcomes from brain injuries.
People with epilepsy frequently report emotional stress in the lead-up to a seizure; but although the association between stress and seizures is well recognised, the mechanisms for this is still not understood. The steroid hormone cortisol is secreted by the body in spurts over the course of the day, and its levels increase dramatically during stress. Cortisol is known to read more
EEG-biofeedback is a non-invasive learning strategy that can enable a person to alter his/her brain wave activity. It has already been shown to be a safe and effective therapeutic option for some adults with epilepsy, but as yet there are no data available for children. Mrs Gina Parker and colleagues, at Birmingham Children’s Hospital NHS Trust, have been awarded £9,965 read more
The most common type of epilepsy is idiopathic (meaning of unknown cause) generalised epilepsy or IGE. When IGE is first diagnosed, most people will be treated with an anti-epileptic drug (AED), but only half will find their seizures stop completely in the following year. There are currently no tests to tell neurologists whether a person will respond to AED treatment, read more
French scientists have identified a molecular imbalance that helps to explain why some patients with a type of brain tumour have epileptic seizures.
Children with a certain form of epilepsy are more likely to experience attention deficit hyperactivity disorder, according to a new study.
A new critical review has highlighted the fact that not enough attention is currently being given to the risks associated with uncontrolled and progressive epilepsy – also known as refractory epilepsy. Eight international epilepsy experts from Europe, the United States, and South America met on May 4th 2013 to present, review and discuss a wide-ranging body of data, concepts and read more
Research has been funded in the US into the development of an implantable neural device that could help to restore memory among patients with epilepsy.
People with childhood-onset epilepsy tend to have a poor recollection of the causes of their condition during their adult years.
A new study has shed light on the demographic and epilepsy-related variables associated with psychosocial function and outcomes in paediatric epilepsy patients.