Brain tumours and epilepsy in children

Compared with the effects of brain tumours in adults, brain tumours in children cause additional problems and complications.

One issue is that they can lead to intractable epilepsy. However the genetic cause of this hard-to-treat epilepsy in paediatric brain tumours is not yet fully understood and nor can it be effectively treated with existing epileptic drugs.

Now a Korean research team has found the first direct evidence that a somatic mutation arising from neural stem cells plays a key role in epileptogenesis in the brain tumour.  The authors said, “Our study offers the first direct evidence that the BRAF somatic mutation arising from neural stem cells plays a key role in epileptogenesis in the brain tumour. This study also showed a new therapeutic target for tumour-associated epileptic disorders.”

To read more about the research please use the link here:

 

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