Anti-epileptic drugs

How can we determine which antiepileptic medication is the best treatment option where monotherapy is the aim?

Posted 16 Nov 2018 in Anti-epileptic drugs / Epilepsy general

For cases of newly diagnosed epilepsy it is often difficult to determine which antiepileptic drug will be the best treatment option where monotherapy is the aim. At the moment Simona Lattanzi and colleagues of the Marche Polytechnic University in Ancona, Italy believe that current approaches do not provide “sufficient data to select an optimal agent as monotherapy for particular patient read more

Alzheimer’s disease and antiepileptic medication

According to a new study from the University of Eastern Finland there is an increased risk of stroke among people with Alzheimer’s who are being treated with antiepileptic drugs.  The incidence of an epilepsy diagnosis is highest in those who are young or in those aged over 65.  Part of the reason for this increase in the older population is read more

Is there a way to determine who will react badly to antiepileptic medication?

Posted 21 Sep 2018 in Anti-epileptic drugs / Living with epilepsy

A quick, easy and inexpensive test could one day help specialists determine which epilepsy patients are likely to react badly to carbamazepine. Carbamazepine is an antiepileptic drug  which is widely used as a first line treatment for epilepsy, but is also prescribed for other conditions, such as bipolar disorder and neuralgia.  However, it can also cause extreme skin conditions in read more

Researchers find protein linked to the treatment of both epilepsy and bipolar disorder

A team of researchers from the Royal Holloway have found that one particular protein which was known to be implicated in both epilepsy and bipolar disorder seems to be the key linking the treatment of both disorders. Sodium valproate which is associated with an increased chance of birth defects if taken during pregnancy, is used in the treatment of both read more

Could a fungus in the Red Sea lead to new epilepsy treatments

Antiepileptic medication controls seizures for the majority of people with epilepsy however between 30-40% of people will not respond to this medication and will not achieve seizure freedom. Researchers are therefore always looking for new compounds that could potentially treat epilepsy and in order to find new leads they have now started to look at the sea as a unique read more

ERUK welcomes new regulations for use of epilepsy drug in women and girls of childbearing age

New regulations for the prescription of anti-epileptic drug have been introduced by the Medicines and Healthcare Regulation Authority (MHRA). Sodium valproate (also known as Epilim, Depakote, Epival, Episenta, and Convulex) can be prescribed for epilepsy, bipolar disorder, and migraine, can no longer be prescribed to women of childbearing age unless they are on a pregnancy prevention plan (PPP). The guidelines read more

Effective epilepsy medication without the side effects?

Posted 9 Mar 2018 in Anti-epileptic drugs

Approximately 60-70% of people with epilepsy will have their seizures controlled with medication. But even when epileptic seizures are controlled with medication the drugs used may have unpleasant, unwanted side effects. Ideally what patients and clinicians are looking for is a drug which works effectively and has no down side. Now new research from the Australian National University aims to read more

Could you be allergic to phenytoin?

Posted 6 Feb 2018 in Anti-epileptic drugs

Finding the right drug to treat epilepsy is always going to be tricky but doctors will always want to prescribe the safest and most beneficial drug for each patient, and these will differ from individual to individual. In some cases the side effects may cause more harm to the patients than the seizures themselves and they may increase the likelihood read more

Jeremy Hunt’s response to valproate pregnancy risks

Posted 15 Oct 2017 in Anti-epileptic drugs / Living with epilepsy

In the lead-up to the EMA hearing on valproate, Clare Pelham, Chief Executive of Epilepsy Society, wrote to Jeremy Hunt, Secretary of State for Health. She asked him to introduce mandatory annual reviews for women who take valproate-related drugs, and who could potentially become pregnant, so that they are fully informed of the risks the drugs pose to unborn babies. The read more

Poll shows that almost 50% of people forget to take their medication at least once a month

Posted 20 Jun 2017 in Anti-epileptic drugs / Living with epilepsy

Patient adherence to medication regimes is a large problem across the world.  Across all medicines, it has been estimated that up to 75% of people do not take their medicines properly.  This could be a problem in epilepsy as a lowering of the medication in the bloodstream could lead to breakthrough seizures.  We wanted to know how often people who read more

Improving drug therapies through more effective targeting

New research from the University of Liverpool, published in the Journal of Clinical Investigation, has identified a protein that could help patients with epilepsy respond more positively to drug therapies. There is now increasing body of evidence showing that local inflammation in the brain may be important in preventing control of seizures. Inflammation refers to the process by which the read more

Diuretic Drug Could Offer Promise in Treating Epilepsy in Future

Posted 2 Mar 2017 in Anti-epileptic drugs

Researchers at the University of Helsinki showed that a change in the function of GABA, the main neurotransmitter in the brain, can cause the formation of incorrect connections between brain cells. These connections may cause epileptic seizures that are difficult to control with drugs. “After a prolonged convulsive seizure, instead of the usual inhibitory effect of the transmitter, GABA accelerates read more

Novel Compound Shows Promising Antiepileptic Effects

Posted 1 Mar 2017 in Anti-epileptic drugs

A new small molecule that can be taken orally, called ADX71149, could have antiepileptic effects on its own or when used in combination with the widely available anti-seizure drug levetiracetam according to experiments conducted in a mouse model of epilepsy, the results of which were published in the scientific journal Epilepsia. Robert Lütjens, Head of Discovery of Addex Therapeutics that co-developed read more

News categories