Grants made in 2012

Understanding the genetics of mesial temporal lobe epilepsy with hippocampal sclerosis: Final Report

This is the final report for a fellowship grant awarded in 2012 for £249,860 to Dr Mar Matarin at UCL.  Mesial temporal lobe epilepsy with hippocampal sclerosis is the most frequent type of epilepsy in people who do not respond well to medication. This type of epilepsy affects some structures of the brain, particularly the hippocampus which is important for read more

The role of autoantibodies in epilepsy: Final Report

This is the final report for a project grant awarded in 2012 for £149,916 to Professor Bethan Lang, Professor Sarosh Irani, Dr Jane Adcock, Dr Holger Kramer, and Professor Arjune Sen at the University of Oxford.  The immune system normally protects a person from infections by making specialised agents called antibodies which normally recognise “foreign targets” and destroy them. Doctors utilise read more

Understanding the mechanisms behind mesial temporal lobe epilepsy

Approximately two thirds of people with epilepsy have seizures successfully controlled with anti-epileptic drugs (AEDs). The remaining third do not respond to AEDs (they are said to have refractory epilepsy (RE)) and for these people, other methods of seizure control must be sought. Brain surgery to remove the seizure origin (the area in which seizures originate) might be an alternative read more

Improving the diagnosis of infantile epileptic encephalopathies

Infantile epileptic encephalopathies (IEEs) include a range of severe epilepsy syndromes, which usually present before the age of 12 months and are associated with intellectual impairment and seizures that are difficult to control. Evidence suggests that families rarely receive a proper explanation about the cause of their child’s IEE, and that even if a genetic abnormality is suspected (as it read more

Restoring learning and memory in temporal lobe epilepsy

Mesial temporal lobe epilepsy (mTLE) is a common type of focal epilepsy, which affects the hippocampus, parahippocampal gyrus and amygdala of the brain. These structures are located in the temporal lobes and have roles in the complex processes of learning, memory and emotion. People affected by mTLE often suffer significant learning impairment and loss of memory; yet the underlying mechanisms read more

Predicting the response to anti-epileptic drug treatment

Posted 6 Jul 2012 in Grants made in 2012

Approximately one-third of people with epilepsy do not respond to anti-epileptic drugs (AEDs), and at present there are currently no ways of predicting whether an AEDwill be effective. Professor  John Terry, at the University of Exeter, and colleagues have recently been awarded £139,595, over 36 months, to carry out a project entitled ‘Developing computer models to improve the predictive value of read more

A new approach to the treatment of absence seizures

Epileptic seizures occur when the neurons of the brain are hyperexcitable. This is usually prevented by the maintenance of a fine balance between excitation and inhibition in the brain, which is brought about by molecules known as neurotransmitters (NTs). NTs allow neurons to communicate with each other and can either be excitatory or inhibitory. An excitatory NT will trigger the read more

The role of autoantibodies in epilepsy

The immune system is our body’s means of defence against harmful substances (toxins, bacteria, viruses) that manage to enter. One of its roles is to produce antibodies, which are designed to selectively destroy disease-causing agents and limit the damage they cause. Occasionally, however, antibodies attack the body itself, leading to an ‘autoimmune’ condition, such as rheumatoid arthritis, or thyroid disease read more

News categories