Grants made in 2013

Genetic & Autoimmune Childhood Epilepsy (GACE) Study: Final Report

This is the final report for a 2013 project grant of £149,481 awarded to Professor Sameer Zuberi at the Royal Hospital for Children in Glasgow. The purpose of this study was to investigate how new genetic testing technologies can improve the diagnosis and treatment of epilepsy. This is the first study of its’ kind, and included all children in Scotland read more

A new tool to study epilepsy genetics

Posted 16 Jul 2013 in Grants made in 2013 / Uncategorized

In recent years there has been a growing interest in epilepsy susceptibility genes, and approximately 13 have been identified in humans to date. Susceptibility genes do not necessarily cause epilepsy, but they render a person more likely to develop it if they are exposed to certain environmental/metabolic triggers. Rodents are very useful in genetic studies for a number of reasons. read more

Finding out who is at risk of epilepsy after a stroke

Posted 16 Jul 2013 in Grants made in 2013

It is widely recognised that having a stroke greatly increases a person’s risk of epilepsy, and statistics show that stroke is the most common cause of epilepsy in people over the age of 60. Every year approximately 150,000 people in the UK suffer a stroke, and this can cause significant brain injury due to bleeding or blockage of the blood supply. read more

Identifying people who are at risk of SUDEP

Posted 15 Jul 2013 in Grants made in 2013

Sudden unexpected death in epilepsy (SUDEP) accounts for approximately 18% of epilepsy-related deaths. There are a number of factors that are thought to increase the risk of SUDEP, including early onset of epilepsy, poor drug compliance and age; however there are certainly other more fundamental ones that have not yet been confirmed. More research is urgently needed, in order that read more

Gaining important new insights into how seizures begin

Posted 26 Jun 2013 in Grants made in 2013

The events leading up to a seizure are still not clear, and this makes it difficult for scientists to design the most effective anti-epileptic drugs. GABA, the main inhibitory neurotransmitter in the brain, is an important regulator of neuronal excitability; and its role in seizure initiation is the focus of much ongoing research. Recent evidence suggests that when epileptic discharges (bursts read more

Improving memory in mesial temporal lobe epilepsy

Posted 26 Jun 2013 in Grants made in 2013

Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy in adults, and seizures normally originate in the hippocampi (singular=hippocampus – important memory centres within the temporal lobes) and other related structures. Imaging of affected individuals frequently shows scarring of the hippocampus, and this is known as hippocampal sclerosis. Unsurprisingly, learning and memory dysfunction are very commonly seen read more

A potential new tool for the diagnosis and treatment of childhood epilepsy

Posted 26 Jun 2013 in Grants made in 2013

In recent years more than 70 genes have been linked to childhood epilepsies, and the search is still ongoing. Autoimmune conditions, in which the body’s immune system produces antibodies against the brain, have also been identified as potential causes of epilepsy and these are treatable. It is not yet known how common these genetic- and immune-mediated epilepsies are in childhood, read more

A new strategy to protect the brain from seizures

Posted 26 Jun 2013 in Grants made in 2013

Reactive oxygen species (ROS), which include a number of free radicals, are thought to play important roles in ageing and cancer; and there is a growing use of anti-oxidants in both cancer therapies and the cosmetics industry. There is increasing evidence that ROS also play a crucial role in the death of neurons in a variety of conditions, including prolonged read more

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