Grants made in 2019

Epilepsy Surgery Pathway: The Lived Experience of Children with Epilepsy, their Parents and Siblings

Lead investigator: Dr Hanna Kovshoff, University of Southampton Co-investigators: Dr Anna Moore, Southampton Children’s Hospital, Prof Sarah Parsons, University of Southampton, Dr Andrea Whitney, Southampton Children’s Hospital, Dr Charlotte Mead Southampton Children’s Hospital Pilot grant: £30,000, 2 years “We want to develop an understanding of child experiences of the epilepsy surgery pathway that takes into account their siblings, parents, peers, read more

Predicting which brain region to treat using a new method of brain mapping

Scientific Title: Predicting which brain region to treat: Multimodal Ictogenic Network Mapping (MINM) Lead investigator: Dr Diana Cash, King’s College London Co-investigators: Dr Michel Mesquita, KCL, Dr Marc Goodfellow, University of Exeter, Dr Laura Mantoan, KCL Collaborator: Prof Mark Richardson, KCL Pilot grant: £29,903, 12 months “Our vision is to establish a translational platform to develop, test and optimise non-invasive read more

Improving diagnostic procedures for epilepsy through automated recording and analysis of patient’s history

Lead investigator: Professor Markus Reuber, University of Sheffield Co-investigators: Dr Heidi Christensen, University of Sheffield, Dr Traci Walker, University of Sheffield Project grant: £75,203, 3 years  “The successful treatment of epilepsy depends on a correct diagnosis. However, it often takes much too long to make the initial diagnoses and too many turn out to be wrong. Despite technological advances the read more

Using new techniques and artificial intelligence to predict patient outcomes following surgery

Scientific Title: Hippocampal shape analysis: a novel practical predictive biomarker of surgical outcome? Lead investigator: Dr Marian Galovic, University College London Co-investigators: Dr Matthias Koepp, UCL Pilot grant: £29,744, 15 months “Epilepsy is frequently treated with a one-size-fits-all approach. We hope that analysing the hippocampus in detail using shape analysis will reveal why some people are more likely to fail epilepsy read more

Identifying the markers of SUDEP using global patient data

Scientific Title: Identifying SUDEP risk: sleep-wakefulness modulation of central autonomic and respiratory networks Lead investigator: Dr Beate Diehl, Institute of Neurology, University College London Co-investigators: Prof Louis Lemieux UCL, Prof Ronald Harper, UCLA Collaborators: Prof Jean Gotman, Montreal Neurological Institute, Prof Stefano Meletti, University of Modena and Reggio Emilia, Prof Graeme Jackson, University of Melbourne, Prof Tyvaert Louise, Universite de read more

Accurately identifying epileptic brain regions using portable MEG

Scientific Title: The use of portable magnetoencephalography (MEG) in epilepsy Lead investigator: Dr Umesh Vivekananda, Institute of Neurology, University College London Co-investigators: Prof Matthew Walker UCL, Prof Gareth Barnes UCL Project grant: £83,958, 3 years “This project aims to develop and use a novel, state-of-the-art form of electrical brain recording called portable Magnetoencephalography. This will likely be able to record read more

2019 ERUK Fellowship Award: Exploring a promising new drug target to stop seizures in their tracks

Scientific Title: Neurogliaform interneurons: a promising inhibitory target to stop focal and generalised seizures Lead investigator: Dr Vincent Magloire, Institute of Neurology, University College London Supervisor: Professor Dimitri Kullmann, Institute of Neurology, University College London Fellowship Award: £247,133, 3 years “With this ERUK study, I will attempt to stop seizures by manipulating the activity of one specific inhibitory cell type. read more

State of the art scanning to investigate absence seizures in children and adolescents

Scientific Title: Thalamic GABA in childhood and juvenile absence epilepsy Lead investigator: Professor Vincenzo Crunelli, Cardiff University Co-investigators: Prof Richard Wise, Cardiff University, Dr Khalid Hamandi, Cardiff and Vale University Health Board, Dr Daniella Brazzo, Cardiff and Vale University Health Board Pilot grant: £30,000, 2 years “We are excited by the possibility of testing our hypothesis with state of the read more

Investigating the underlying mechanisms of Sudden Unexpected Death in Epilepsy (SUDEP)

Scientific Title: Do microglia prevent seizure-induced cardiorespiratory dysfunction? Lead investigator: Professor Nicholas Dale, University of Warwick Co-investigators: Dr Amol Bhandare, University of Warwick Project grant: £172,218, 2 years “Anaesthesia depresses neural activity, therefore being able to image the brainstem cardiorespiratory neuronal network and beneficial effects of microglial activation or inhibition during seizures in freely behaving animals offers therapeutic strategies to read more

Predicting and reducing language deficits from temporal lobe epilepsy surgery

Lead investigator: Dr Sjoerd Vos, Department of Medical Physics and Biomedical Engineering, University College London Co-investigators: Prof John Duncan, UCL, Dr Peter Taylor, Newcastle University, Dr Pamela Thompson, UCL,  Dr Sallie Baxendale, UCL Project grant: £163,573, 3 years “Our project aims to improve treatment options in those people who do not benefit from epilepsy medication. In the right cases, surgery read more

News categories