Other treatments

Guidelines Comparing Assessment Techniques Prior to Epilepsy Surgery Published

Posted 20 Jan 2017 in Other treatments

The American Academy of Neurology (AAN) has published new guidelines on mapping of the brain prior to epilepsy surgery, following a systematic review of available evidence. The guidelines were published in the academy’s journal Neurology and compared results of functional magnetic resonance imaging (fMRI), a type of scan that assesses brain activity by measuring blood flow, with data obtained from read more

People with Drug Resistant Nonlesional Neocortical Epilepsy Could Benefit from Brain Surgery

Posted 10 Jan 2017 in Other treatments

People with nonlesional neocortical epilepsy could benefit from brain surgery and become seizure-free in the long term according to a study published in the scientific journal JAMA Neurology. Dr Dong Wook Kim and colleagues explored factors that might help select people with nonlesional neocortical epilepsy who are most likely to benefit from surgery. The researchers analysed data from 109 people, aged read more

Cannabidiol May Reduce the Frequency and Severity of Epileptic Seizures

Posted 12 Dec 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. Treatment with cannabidiol (CBD) improves the frequency and severity of seizures in children and adults with epilepsy, according to research presented at the American Epilepsy Society annual meeting in Huston, Texas. The findings are based on an open label,* expanded access clinical trial to test the read more

Modifying AEDs Used by Patients During Vagal Nerve Stimulation Does Not Improve Outcome

Posted 28 Nov 2016 in Other treatments

Changing people’s antiepileptic drugs (AEDs) during vagal nerve stimulation (VNS) does not seem to improve their outcomes, according to a study published in the journal Acta Neurochirurgica. On the basis of this finding, the authors suggest that keeping the same AEDs following the implantation of a VNS device may help optimise its parameters and could improve its effectiveness. In order to read more

Children with Epilepsy on the Ketogenic Diet Should Have their Blood Selenium Levels Closely Monitored

Posted 25 Nov 2016 in Epilepsy in children / Other treatments

An olive oil-based ketogenic-diet leads to a decline in selenium levels in children with drug-resistant epilepsy, according to a study published in the journal of Biological Trace Elements Research. Previous research has shown that low amount of selenium, an element found in trace amounts in the blood that, may increase the risk of seizures. Therefore the levels of selenium in read more

Electrical Brain Stimulation to Treat Drug Resistant Epilepsy in Children

Posted 21 Nov 2016 in Other treatments

The findings of a small study, led by researchers at King’s College London, suggest that electrical stimulation of the brain may be a safe and effective treatment for children with drug-resistant epilepsy, although further research is required. The work is published in the European Journal of Paediatric Neurology. Limited information exists about the effects of brain stimulation in children and, read more

New Antiepileptic Drug Candidate Discovered

Posted 8 Nov 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. Researchers at Elli Lilly and Co., in Indiana, have discovered a new compound that specifically targets neural circuits involved in epilepsy and could potentially be developed into an antiepileptic drug (AED). The findings are published in the leading scientific journal, Nature Medicine. The compound, known as CERC-611, selectively blocks read more

Epilepsy Surgery in the Back of the Brain Can Achieve Excellent Results if Performed Early, Study Suggests

Posted 30 Oct 2016 in Other treatments

Surgery in the back of the brain can attain excellent results if it is conducted early, according to a study published in the scientific journal, Epilepsy and Behavior. Currently this type of surgery is rarely performed, because it is associated with a high number of failures due to the fact that it is extremely difficult to localise the origin from read more

New Compound Could Protect Against the Development of Seizures in Drug-Resistant Epilepsy

Posted 25 Oct 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. A study has shown that huperzine A, a naturally occurring compound often used in traditional Chinese medicine, has a protective effect against experimentally-induced seizures in rodent models of epilepsy. The work is published in the scientific journal, Frontiers in Pharmacology. According to the authors, huperzine A may therefore provide a read more

Epilepsy Surgery in Childhood Does Not Seem to Improve Memory Over Time

Posted 14 Oct 2016 in Other treatments

A new study published in the journal, Epilepsia, suggests that short-term improvements in memory following childhood epilepsy surgery might not be sustained in the long term. These findings may be helpful for physicians, people with epilepsy and their families to better understand the possible outcomes of epilepsy surgery in childhood, and the effects of continuing antiepileptic drug (AED) treatment. For the read more

Surgery Could Improve Psychiatric Problems in Epilepsy

Posted 8 Oct 2016 in Other treatments

Surgery for refractory (drug-resistant) epilepsy may improve psychological changes and psychiatric problems seen in some people with epilepsy, according to a study published in the scientific journal, Epilepsia. First Author Dr Sònia Ramos-Perdigués, at Can Misses Hospital, in Spain, said: “The results of this study suggest that surgery for refractory epilepsy may provide additional benefit in patients with a psychiatric history and read more

Results from Clinical Trial Show Promise for Children with PCDH19 Epilepsy

Posted 1 Oct 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. Marinus Pharmaceuticals has announced the results of a phase two clinical trial evaluating its drug candidate, ganaxolone, for the treatment of PCDH19 epilepsy. They show that ganaxolone was generally safe, well-tolerated and reduced seizure frequency in most participants. In a press release, Dr Michael G. Chez, Paediatric Neurologist at Sutter Medical read more

New Animal Model of Epilepsy Could Help Develop Novel AEDs

Posted 29 Sep 2016 in Other treatments

Researchers at Florida Atlantic University and The Scripps Research Institute,  in the US, have developed a new animal model of epilepsy that will allow the screening of hundreds of thousands of potential antiepileptic compounds. This work is published in the leading scientific journal, Plos One The team, led by Dr Ken Dawson-Scully, genetically modified microscopic worms called C. elegans and were able to chemically or read more

Continuous Electrical Brain Stimulation Could be a Treatment Option for People with Drug-Resistant Epilepsy

Posted 22 Sep 2016 in Other treatments

Continuous electrical brain stimulation could help to suppress epileptic seizures, offering a new treatment option for people who have epilepsy that cannot be treated with surgery or medication. These findings are published in JAMA Neurology, First Author Dr Brian Lundstrom, at Mayo Clinic in Rochester, US, said: “We think this approach not only provides an effective treatment for those with focal epilepsy, but read more

Do Omega-3 Supplements Have a Beneficial Effect in Drug-Resistant Epilepsy?

Posted 14 Sep 2016 in Other treatments

Scientists in Brazil suggest that the benefits of omega-3 supplements in people with drug-resistant epilepsy require further investigation. This comes after literature review, published in Cochrane Database of Systemic Reviews. To assess the effectiveness and tolerability of omega-3 supplements in the control of seizures in people with drug-resistant epilepsy, the researchers, from Universidade Estadual de Ciências da Saúde de Alagoas, read more

Promising Results From Phase Three Clinical Trial for People With Tuberous Sclerosis Complex

Posted 8 Sep 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. The antiepileptic drug (AED) everolimus significantly reduces seizure frequency in people with drug-resistant epilepsy and tuberous sclerosis complex (TSC), according to a study published in the leading medical journal The Lancet. The phase three clinical trial was conducted by a team of researchers led by Dr David read more

The ketogenic diet shows mood and behavioural benefits in children

Posted 6 Sep 2016 in Other treatments

The ketogenic diet may have a positive impact on behaviour and thinking skills in children with drug-resistant epilepsy, according to a study conducted in the Netherlands. The results are published in the scientific journal Epilepsy and Behavior. The randomised controlled trial, led by Dr Albert Aldenkamp, from Epilepsy Center Kempenhaeghe, recruited 50 children with drug-resistant epilepsy, aged between one and 18 years. After a one-month read more

Small Device Could Detect and Stop Epileptic Seizures on the Spot

Posted 25 Aug 2016 in Other treatments

Researchers in Sweden and France have developed a tiny device that can detect epileptic seizures at the exact point in which they arise, and deliver, to that precise point, a substance that can stop them before they spread to other areas of the brain. The device, called a bioelectronic neural pixel, is 20×20 μm* in size (approximately the size of a read more

Epilepsy surgery in childhood does not impact on language in the long term

Posted 22 Aug 2016 in Other treatments

Language skills remain largely unchanged following epilepsy surgery in childhood, according to new research published in the scientific journal Epilepsy and Behaviour. There have been few investigations into brain function after epilepsy surgery in childhood, and these have largely focused on memory and intelligence rather than language. During the current study, researchers at the Hospital for Sick Children, in Toronto, recruited 97 children who read more

‘Sirolimus’ for seizures in tuberous sclerosis complex needs further investigation

Posted 18 Aug 2016 in Other treatments

According to a recent study, published in the journal Neurology, sirolimus* add-on treatment does not significantly reduce seizure frequency in children with tuberous sclerosis complex (TSC) and drug-resistant epilepsy. The authors state, however, that due the small size of the study, larger ones are needed to verify this finding. TSC is a genetic condition that causes tumours to form in different read more

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