Researchers at Florida Atlantic University and The Scripps Research Institute, in the US, have developed a new animal model of epilepsy that will allow the screening of hundreds of thousands of potential antiepileptic compounds. This work is published in the leading scientific journal, Plos One The team, led by Dr Ken Dawson-Scully, genetically modified microscopic worms called C. elegans and were able to chemically or read more
Continuous Electrical Brain Stimulation Could be a Treatment Option for People with Drug-Resistant Epilepsy
Continuous electrical brain stimulation could help to suppress epileptic seizures, offering a new treatment option for people who have epilepsy that cannot be treated with surgery or medication. These findings are published in JAMA Neurology, First Author Dr Brian Lundstrom, at Mayo Clinic in Rochester, US, said: “We think this approach not only provides an effective treatment for those with focal epilepsy, but read more
Scientists in Brazil suggest that the benefits of omega-3 supplements in people with drug-resistant epilepsy require further investigation. This comes after literature review, published in Cochrane Database of Systemic Reviews. To assess the effectiveness and tolerability of omega-3 supplements in the control of seizures in people with drug-resistant epilepsy, the researchers, from Universidade Estadual de Ciências da Saúde de Alagoas, read more
Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. The antiepileptic drug (AED) everolimus significantly reduces seizure frequency in people with drug-resistant epilepsy and tuberous sclerosis complex (TSC), according to a study published in the leading medical journal The Lancet. The phase three clinical trial was conducted by a team of researchers led by Dr David read more
The ketogenic diet may have a positive impact on behaviour and thinking skills in children with drug-resistant epilepsy, according to a study conducted in the Netherlands. The results are published in the scientific journal Epilepsy and Behavior. The randomised controlled trial, led by Dr Albert Aldenkamp, from Epilepsy Center Kempenhaeghe, recruited 50 children with drug-resistant epilepsy, aged between one and 18 years. After a one-month read more
Researchers in Sweden and France have developed a tiny device that can detect epileptic seizures at the exact point in which they arise, and deliver, to that precise point, a substance that can stop them before they spread to other areas of the brain. The device, called a bioelectronic neural pixel, is 20×20 μm* in size (approximately the size of a read more
Language skills remain largely unchanged following epilepsy surgery in childhood, according to new research published in the scientific journal Epilepsy and Behaviour. There have been few investigations into brain function after epilepsy surgery in childhood, and these have largely focused on memory and intelligence rather than language. During the current study, researchers at the Hospital for Sick Children, in Toronto, recruited 97 children who read more
According to a recent study, published in the journal Neurology, sirolimus* add-on treatment does not significantly reduce seizure frequency in children with tuberous sclerosis complex (TSC) and drug-resistant epilepsy. The authors state, however, that due the small size of the study, larger ones are needed to verify this finding. TSC is a genetic condition that causes tumours to form in different read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any commercial company, or any particular device/product. The medical company, MMJ PhytoTech Limited, has recently announced that it will begin a new phase two clinical trial by the end of this year to test the effectiveness of its new drug compound, PTL101, in treating children with drug-resistant epilepsy. During the trial, read more
Sodium selenate could be used to slow the progression of epilepsy-causing changes in the brain, according to a new study published in the scientific journal Brain. The compound could one day even be used to prevent epilepsy that occurs as a result of head injury. Professor Terry O’Brien, a neurologist from the Royal Melbourne Hospital and senior author of the read more
Researchers at the University of Exeter have developed an advanced computer model that can identify where in the brain epileptic seizures originate. It can also distinguish, with high accuracy, between the source of a person’s seizures and brain regions that become involved as a result of the seizure starting. This technique could help epilepsy surgeons to identify more accurately the region(s) of read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any commercial company, or any particular device/product. Medtronic plc, a medical device company based in Dublin, announced on Friday that the US Food and Drug Administration (FDA) has approved the testing of its Visualase(TM) laser ablation system in a clinical trial. The device will now be used in a read more
People with epilepsy frequently report emotional stress/anxiety in the lead-up to a seizure; but although the association between stress and seizures is well recognised, the underlying mechanisms are still not understood. A research study, published yesterday in the journal Science Signaling, has produced exciting findings that may help the development of new strategies to treat stress-induced epilepsy. Using a rodent model read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any pharmaceutical company, or any particular drug compound. Marinus Pharmaceuticals announced yesterday that their drug candidate, ganaxolone, developed for adults with drug-resistant focal onset epilepsy, did not meet the ‘primary endpoint’ (the outcome by which the effectiveness of treatments is evaluated) in a phase three clinical trial. In other read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any pharmaceutical company, or any particular drug compound. The pharmaceutical company, Zogenix, has announced the start of a new clinical trial for a drug compound called ZX008, which it has developed for the treatment of Dravet syndrome. About Dravet syndrome Dravet syndrome is a rare and severe form of read more
Researchers at Yale University have succeeded in developing a ‘representative’ experimental model of focal cortical dysplasia, a common cause of drug-resistant epilepsy. This new tool is likely to be instrumental in improving our understanding of the condition and developing new treatments.
Research suggests that the outcome of epilepsy surgery may depend on a person’s genes.
Systemic family therapy can help to improve signs of anxiety and depression in adolescents with epilepsy, according to a new study.
People with epilepsy treated with vagus nerve stimulation have a reduced risk of sudden unexpected death in epilepsy, according to a new study.
A recent study has shown encouraging evidence for the long-term efficacy of fenfluramine in the treatment of Dravet syndrome, a rare and therapy-resistant epilepsy syndrome. The research, carried out by the University of Antwerp, built on an earlier study of add-on fenfluramine treatment in 12 patients with Dravet syndrome, which was published in 2012. The findings suggested that the drug has a beneficial read more