Language skills remain largely unchanged following epilepsy surgery in childhood, according to new research published in the scientific journal Epilepsy and Behaviour. There have been few investigations into brain function after epilepsy surgery in childhood, and these have largely focused on memory and intelligence rather than language. During the current study, researchers at the Hospital for Sick Children, in Toronto, recruited 97 children who read more
According to a recent study, published in the journal Neurology, sirolimus* add-on treatment does not significantly reduce seizure frequency in children with tuberous sclerosis complex (TSC) and drug-resistant epilepsy. The authors state, however, that due the small size of the study, larger ones are needed to verify this finding. TSC is a genetic condition that causes tumours to form in different read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any commercial company, or any particular device/product. The medical company, MMJ PhytoTech Limited, has recently announced that it will begin a new phase two clinical trial by the end of this year to test the effectiveness of its new drug compound, PTL101, in treating children with drug-resistant epilepsy. During the trial, read more
Sodium selenate could be used to slow the progression of epilepsy-causing changes in the brain, according to a new study published in the scientific journal Brain. The compound could one day even be used to prevent epilepsy that occurs as a result of head injury. Professor Terry O’Brien, a neurologist from the Royal Melbourne Hospital and senior author of the read more
Researchers at the University of Exeter have developed an advanced computer model that can identify where in the brain epileptic seizures originate. It can also distinguish, with high accuracy, between the source of a person’s seizures and brain regions that become involved as a result of the seizure starting. This technique could help epilepsy surgeons to identify more accurately the region(s) of read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any commercial company, or any particular device/product. Medtronic plc, a medical device company based in Dublin, announced on Friday that the US Food and Drug Administration (FDA) has approved the testing of its Visualase(TM) laser ablation system in a clinical trial. The device will now be used in a read more
People with epilepsy frequently report emotional stress/anxiety in the lead-up to a seizure; but although the association between stress and seizures is well recognised, the underlying mechanisms are still not understood. A research study, published yesterday in the journal Science Signaling, has produced exciting findings that may help the development of new strategies to treat stress-induced epilepsy. Using a rodent model read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any pharmaceutical company, or any particular drug compound. Marinus Pharmaceuticals announced yesterday that their drug candidate, ganaxolone, developed for adults with drug-resistant focal onset epilepsy, did not meet the ‘primary endpoint’ (the outcome by which the effectiveness of treatments is evaluated) in a phase three clinical trial. In other read more
Disclaimer: Epilepsy Research UK is completely neutral and is not affiliated with any pharmaceutical company, or any particular drug compound. The pharmaceutical company, Zogenix, has announced the start of a new clinical trial for a drug compound called ZX008, which it has developed for the treatment of Dravet syndrome. About Dravet syndrome Dravet syndrome is a rare and severe form of read more
Researchers at Yale University have succeeded in developing a ‘representative’ experimental model of focal cortical dysplasia, a common cause of drug-resistant epilepsy. This new tool is likely to be instrumental in improving our understanding of the condition and developing new treatments.
Research suggests that the outcome of epilepsy surgery may depend on a person’s genes.
Systemic family therapy can help to improve signs of anxiety and depression in adolescents with epilepsy, according to a new study.
People with epilepsy treated with vagus nerve stimulation have a reduced risk of sudden unexpected death in epilepsy, according to a new study.
A recent study has shown encouraging evidence for the long-term efficacy of fenfluramine in the treatment of Dravet syndrome, a rare and therapy-resistant epilepsy syndrome. The research, carried out by the University of Antwerp, built on an earlier study of add-on fenfluramine treatment in 12 patients with Dravet syndrome, which was published in 2012. The findings suggested that the drug has a beneficial read more
New UK research has shed light on the potentially negative impact the “burden of normality” can have on the mental outlook of people with epilepsy. Led by St James’ Hospital in Leeds, the study aimed to explore the relationship between psychosocial characteristics prior to epilepsy surgery and quality-of-life outcomes following the operation, with the goal of identifying risk factors for poor read more
A new study has indicated that oestrogen-blocking therapies called aromatase inhibitors could be useful in helping to control seizures.
A new study has demonstrated the benefits of the ketogenic diet in the treatment of children and adolescents with refractory (drug-resistant) epilepsy. Led by Maastricht University, the research aimed to evaluate the efficacy and tolerability of the high-fat, moderate-protein, low-carbohydrate diet, during the first four months of a controlled trial in children with refractory epilepsy aged 1-18 years. After one month’s baseline assessment, enrolled read more
A new research project has gotten underway that aims to create an implantable neural monitoring and stimulation system to help improve memory among people with epilepsy and other conditions.
A new minimally invasive brain-machine interface has been developed that could aid the treatment and management of epilepsy in future.
A new study has highlighted the need for epilepsy surgery patients to be provided with more information to help them have a better experience before and after their operations.