Epileptiform discharges in FE patients linked to subsequent epilepsy

Posted Mar 4 2014 in Conditions related to epilepsy

Children who show epileptiform discharges following the diagnosis of fever-induced seizures are more likely to develop epilepsy in the longer term, according to a recent study.

The report, which was published in last month’s edition of Clinical EEG Neuroscience, compared the records of 378 patients with complex febrile seizures (FS), each undergoing an electroencephalogram (EEG) following their diagnosis.

Some 51 children showed epileptiform discharges during their EEG, while the rest of the cohort had normal brain activity.

A number of risk factors were found in the patients with epileptiform discharges, including a family history of epilepsy, a high frequency of FS episodes and the length of time those seizures lasted.

Subjects with more than two risk factors were significantly more likely to develop the neurological condition in the long-run, leading the researchers to conclude that epileptiform discharges are a reliable indicator of an FS patient’s epilepsy risk.

This was more pronounced in subjects whose paroxysms affected the frontal region of the brain, of whom eight of nine (89 per cent) developed epilepsy.

Posted by Steve Long

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