Genetic epilepsies respond to epilepsy surgery in different ways
Technological advances in recent years mean that it is now easier, and considerably cheaper, to test people with epilepsy for underlying genetic causes. As a result of this, scientists have been able to uncover new genetic abnormalities linked to epilepsy. If scientists can understand the causes of a person’s epilepsy, they may be able to provide improved epilepsy treatments. This is particularly relevant for people with refractory epilepsy, which is epilepsy that does not respond to drug therapy.
Researchers at the University Medical Centre of Utrecht combined 24 existing scientific research articles on seizure outcome following epilepsy surgery. These articles detailed a total of 82 patients with 15 different genetic causes of drug-resistant epilepsy. All patients underwent surgery, and a successful surgery was defined as one which left the patient free of seizures. The combined research indicated that certain genetic epilepsies had much higher success rates following surgery than others.
The scientists admitted that evidence in this area is scarce, however the results from their study suggest that genetic testing may enable doctors to predict whether a surgery will be successful or not. It is hoped that this research may lead to improved surgical techniques for patients with refractory epilepsy. To read more about this review, you can use the link here: