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Below are the most recent news stories about epilepsy from Epilepsy Research UK and from around the world. You can choose different categories from the side bar on the left (for details of grants made prior to 2012, please visit our research portfolio). You can also catch up with Epilepsy Research UK's fundraising and research news in our supporter newsletters.

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PAR1 Involved in Regulating Anxiety-Related Behaviour

Posted 21 Jan 2017 in Conditions related to epilepsy

A major receptor found in the brain called PAR1 is involved in the regulation of anxiety-related behaviour, suggests a recent study, published in the journal Epilepsy and Behavior. The study used an animal model of temporal lobe epilepsy (TLE), the most common type of focal epilepsy in adults, which is often associated with psychiatric complications such as depression and anxiety. read more

Guidelines Comparing Assessment Techniques Prior to Epilepsy Surgery Published

Posted 20 Jan 2017 in Other treatments

The American Academy of Neurology (AAN) has published new guidelines on mapping of the brain prior to epilepsy surgery, following a systematic review of available evidence. The guidelines were published in the academy’s journal Neurology and compared results of functional magnetic resonance imaging (fMRI), a type of scan that assesses brain activity by measuring blood flow, with data obtained from read more

Testing of a Modified Antiepileptic Drug in Healthy Volunteers Completed

Adamas, a pharmaceutical company based in California, has announced the completion of a Phase1 clinical trial testing the drug candidate ADS-4101 for the treatment of partial onset seizures. ADS-4101 is a new version of the existing antiepileptic drug (AED) lacosamide (Vimpat®) that is already approved by the US Food and Drug Administration (FDA) and the European Medicine Agency (EMA). However read more

Get active for research!

Posted 18 Jan 2017 in News from Epilepsy Research UK

This year  once again brings a fantastic events calendar with lots of exciting sporting events and challenges to get involved in! Proudly wear your green ERUK colours and make 2017 our best year yet! Join Team ERUK No matter what your ability there is something for everyone.  Whether a 5K Fun Run, Sponsored Walk, Marathon or Cycle event there is read more

Common and Rare Epilepsies Share Genetic Mutations

Posted 18 Jan 2017 in Brain science; genetics

Several genes previously thought to be associated with only rare types of epilepsy seen in children are also involved in more common types of the condition, according to a study published in the scientific journal The Lancet Neurology. This finding suggests that therapeutic approaches, which target the precise genetic cause of epilepsy and which are used to tackle rare forms read more

People with Drug Resistant Nonlesional Neocortical Epilepsy Could Benefit from Brain Surgery

Posted 10 Jan 2017 in Other treatments

People with nonlesional neocortical epilepsy could benefit from brain surgery and become seizure-free in the long term according to a study published in the scientific journal JAMA Neurology. Dr Dong Wook Kim and colleagues explored factors that might help select people with nonlesional neocortical epilepsy who are most likely to benefit from surgery. The researchers analysed data from 109 people, aged read more

Nasal Spray to Treat Cluster Seizures Gets Fast-Track Designation from the FDA

The pharmaceutical company Neurelis Inc. recently announced that the US Food and Drug Administration (FDA) has granted fast-track designation for NRL-1, a special formulation of diazepam, for the treatment of epilepsies that are characterised by clusters of seizures. This means that the new formulation could become available more quickly. “We are very excited to have received Fast Track Designation status read more

ADHD Drug Could Improve Brain Function in People with Epilepsy

Posted 5 Jan 2017 in Conditions related to epilepsy

Methylphenidate (MPH), a drug used for the treatment of attention deficit and hyperactivity disorder (ADHD), could improve cognitive problems in people with epilepsy, according to a study published in the scientific journal Neurology. This suggestion is based on the results of a clinical trial that included 35 adults with epilepsy aged between 20 and 62 years, who had long-standing cognitive read more

Gene Associated with Bipolar Disorder also Linked to Epilepsy

Posted 5 Jan 2017 in Brain science; genetics

A gene called ANK3, which is associated with bipolar disorder (formerly known as manic depression) could also be linked to epilepsy, according to a study published in the scientific journal Molecular Psychology. This new finding means that ANK3 could be targeted and opens new potential avenues for the treatment of epilepsy. Research led by Dr Edward Cooper, at Baylor College read more

Continuous EEG Recording Could Help Doctors Identify People Most at Risk of Developing Seizures

Posted 3 Jan 2017 in Brain science; genetics

Continuous electroencephalographic (EEG) monitoring and a detailed interpretation of the data obtained from such monitoring could help doctors classify patients according to their risk of having seizures, according to a study published in the medical journal JAMA Neurology. This knowledge could help them make better clinical decisions such as treating those at higher risk of seizures with more aggressive treatment approaches. In read more

Study Sheds Light Onto How Flashing Images May Trigger Epileptic Seizures

Posted 21 Dec 2016 in Brain science; genetics

A new study published in the scientific journal, NeuroImage, may help explain how rhythmic stimulations at certain frequencies such as flickering images can lead to epileptic seizures. In a press release, Senior Author Dr Marc Goodfellow, at the University of Exeter, said: “Our findings help to elucidate mechanisms of the generation and spreading of epileptic seizures in the brain”. The read more

Rabbi Lionel Blue

Posted 21 Dec 2016 in News from Epilepsy Research UK

Rabbi Lionel Blue passed away on 19th December, aged 86. Rabbi Blue was diagnosed with epilepsy at age 57 and was one of the first people to talk openly about the condition and how it affected his life.    Rabbi Blue was a greatly valued friend of Epilepsy Research UK. He served as Vice President of the Epilepsy Research Foundation, and read more

Professor Brian Neville

Posted 20 Dec 2016 in News from Epilepsy Research UK

It is with great sadness that we announce the death of Professor Brian Neville, Emeritus Professor of Paediatric Neurology at University College London – Institute of Child Health (UCL-ICH).  Brian was a great ambassador for epilepsy and dedicated his life to improving the lives of children and young people with the condition. He held the first Prince of Wales’s Chair of read more

Absence Seizures Could Be Prevented, Experimental Study Suggests

Posted 20 Dec 2016 in Brain science; genetics

It may be possible to reduce, stop or even prevent absence seizures, the most common form of childhood epilepsy, according to a study published in the leading scientific journal Neuron. Using an advanced technology called optogenetics and a rodent model, researchers at Stanford University School of Medicine showed that it is possible to trigger seizures by inducing synchronized, rhythmic activity read more

Neural Stem Cells Found in Brain Tissue Removed During Epilepsy Surgery

Posted 19 Dec 2016 in Brain science; genetics

Researchers at the University of Gothenburg, in Sweden, have found neural stem cells in epileptic brain tissue where they normally do not reside. This work is published in the scientific journal, Cerebral Cortex. Neural stem cells are immature cells in the brain that are able to mature into neurons, astrocytes (non-neuronal support cells) or oligodendrocytes (producers of myelin, which is needed for effective read more

Scientists Identify Network of Genes that Could Be Targeted to Treat Epilepsy

Posted 14 Dec 2016 in Brain science; genetics

Researchers led by Professor Michael Johnson, at Imperial College London, have identified a network of genes that is associated with epilepsy. The team believes that targeting the expression of this “epileptic network” of 320 genes, which they called M30, could be a new strategy to treat the condition. In a news release, Professor Johnson said: “The discovery of this network of genes read more

Carbamazepine Safe and Effective in Newborn Babies with Epilepsy

Posted 13 Dec 2016 in Epilepsy in children

A new study published in the scientific journal, Epilepsia, suggests that low-dose oral carbamazepine (CBZ – an antiepileptic drug) is safe and effective in newborn babies with benign familial neonatal epilepsy (BFNE); even in status epilepticus where the seizures occur very close together or last a long time. The authors therefore propose that CBZ should be the drug of choice read more

Cannabidiol May Reduce the Frequency and Severity of Epileptic Seizures

Posted 12 Dec 2016 in Other treatments

Please note that Epilepsy Research UK does not endorse/promote individual epilepsy treatments or pharmaceutical companies. Treatment with cannabidiol (CBD) improves the frequency and severity of seizures in children and adults with epilepsy, according to research presented at the American Epilepsy Society annual meeting in Huston, Texas. The findings are based on an open label,* expanded access clinical trial to test the read more

Outcome of AED Therapy Similar in People with Epilepsy Related to Blood Vessel Malformation and People with General Epilepsy

The outcome of antiepileptic drug (AED) therapy in people with epilepsy related to blood vessel malformation in the brain is similar to the outcome of  those with ‘general’ epilepsy, according to a study published in the scientific journal Seizure. According to the authors, failure to achieve seizure-freedom after the adequate trial of two AEDs seems an appropriate criterion for surgical referral of read more

Factors Contributing to Anxiety and Depression One Year After Being Diagnosed with Epilepsy

Posted 8 Dec 2016 in Conditions related to epilepsy

Lack of social support is a risk factor for developing anxiety and depression one year after being diagnosed with epilepsy, according to results presented at the American Epilepsy Society’s annual meeting in Houston, Texas. The findings also suggest that epilepsy-related factors such as the number of antiepileptic drugs (AEDs) a person is prescribed and seizure recurrence also significantly contribute to depression one year after read more

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