Grant Announcements 2016: “Individuals who carry mutations in genes that encode receptors activated by the excitatory neurotransmitter, glutamate, can suffer from a variety of disorders, many of which are associated with epilepsy. While our previous research has focused on studying glutamate receptors and their role in neuronal communication, the project funded by ERUK allows us to extend our work to a pre-clinical model that is a direct correlate of epileptic encephalopathy.” Professor David Wyllie
Grant Announcements 2016: “Forward-thinking strategies for the most difficult-to-treat types of epilepsy are desperately needed. I will test whether controlling the activity of entire seizure-generating networks, as opposed to just the seizure foci, can be a more effective treatment to block seizures. To do so, I will use the technology of optogenetics, which has the potential to be translated to the clinic in the coming years, but can also “shine a light” on novel cellular targets to efficiently block seizures for other forms of clinical interventions.” Alfredo Gonzalez-Sulser
Grant Announcements 2016: “This is an exciting project that will give significant insights into the feasibility of cell transplantation for treating seizures and cognitive problems in patients with temporal lobe epilepsy.” Professor Liam Gray
Grant Announcements 2016: “We are really grateful to Epilepsy Research UK for offering us the possibility of exploring this exciting approach. If the new PET-MRI scanner methods help us find where these patients’ seizures come from, many more patients will be able to undergo surgery in the future.” Professor Alexander Hammers
Grant Announcements 2016: “Our data will indicate whether offering a standard sleep assessment using sleep diaries or actigraphy for newly diagnosed infants would be a low-cost and effective way to avoid cascading consequences of early sleep problems on subsequent socio-cognitive development. Since sleep is a modifiable risk factor, sleep problems could be addressed if picked up early, which could reduce seizure incidence, lead to an increased quality of life of families and save costs.
We also aim to communicate the results of our study to caregivers and clinicians as quickly as possible in order to draw their attention onto the importance of sleep in early onset epilepsy.” Dr Manuela Pisch
A new algorithm developed by computer scientists and mathematicians has shown potential to help predict and warn people with epilepsy against imminent seizures.
New advances in treating status epilepticus are helping to reduce mortality rates associated with the condition in England and Wales. A recent study, led by Queen Mary University of London and University College London, reviewed data from the Office of National Statistics and offered evidence that early treatment of this dangerous condition could improve outcomes. Status epilepticus is characterised by read more
A new study has offered evidence that cases of insomnia in people with epilepsy may not be directly caused by their condition. Conducted by South Korea’s Soonchunhyang University College of Medicine, in association with three US centres, the research suggested that depression and other comorbid conditions have more to do with causing insomnia than epilepsy itself. Of the 90 adults read more
Taken directly from RCPCH: The Royal College of Paediatrics and Child Health (RCPCH) has published the Infants’, Children’s and Young People’s Child Health Research Charter. This Research Charter has been developed by the RCPCH with children, young people, parents, carers and healthcare professionals, to provide guiding principles for anyone; whether that be a child, young person, parent, doctor, nurse, allied healthcare read more
A new study has indicated that oestrogen-blocking therapies called aromatase inhibitors could be useful in helping to control seizures.
A new study has demonstrated the effectiveness of intravenous lacosamide in the treatment of various forms of epilepsy.
A new study has offered evidence that immediate antiepileptic drug treatment following an initial unprovoked seizure may not always be the best course of action.
Medical staff could be doing more to help patients cope with the stress and anxiety that can often accompany caring for children with epilepsy.
Using a wrist accelerometer linked to an online database could be a more effective method of monitoring seizure trends among people with epilepsy.
A new study has outlined the measures that people with epilepsy and their carers consider most important when carrying out clinical trials of epilepsy. For this research, led by the University of Liverpool, 352 people with epilepsy and 263 of their ‘informal carers’ (usually a parent/spouse) were presented with ten outcome areas and asked to rate their importance. They were also asked read more
Researchers at New York University have uncovered vital new clues as to why many people with epilepsy experience memory problems. Background The formation of memories requires extremely precise co-ordination of activity between the brain cortex (the brain’s folded surface) and the hippocampus (found deep within the temporal lobes). Previous studies have shown that spontaneous bursts (SBs) of epileptic activity in the brain in between seizures read more
A new study has indicated that many children with epilepsy have a good level of insight and understanding into the nature of their condition.
Interim findings from ERUK fellowship: Cutting-edge techniques to explore brain cell activity in epilepsy
Background Focal epilepsies that originate in a specific part of the brain cortex are often resistant to existing anti-epileptic drugs, and there is an urgent need for new treatment strategies. Previous experimental research into these focal epilepsies has largely focused on acute seizures that have been purposefully induced in isolated brain tissue where long-range connections between neurons have been severed. read more
‘Waking up to epilepsy’, hosted by University of Exeter Medical School, was a one-day educational meeting open to anyone with an interest in learning about epilepsy. Epilepsy Research UK supported the event, which took place on 20 April 2016, and here our research manager gives an account of the day. “Waking up to epilepsy was a great success, with over read more
A new UK study has highlighted the need for more research into the impact that the use of different terms to describe people with epilepsy can have on them.