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Below are the most recent news stories about epilepsy from Epilepsy Research UK and from around the world. You can choose different categories from the side bar on the left (for details of grants made prior to 2012, please visit our research portfolio). You can also catch up with Epilepsy Research UK's fundraising and research news in our supporter newsletters.

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Intranasal midazolam shows seizure protection benefits

A new study from Germany has demonstrated the potential benefits that intranasal midazolam can offer in the treatment of presurgical epilepsy. The research, published in the medical journal Epilepsia, evaluated the tolerability and efficacy of the ictal and immediate postictal application of intranasal midazolam in adolescents and adults during video-electroencephalography monitoring. A total of 75 patients were treated with the read more

Ketogenic diet ‘effective for children with refractory epilepsy’

Posted 28 Jul 2015 in Epilepsy in children

A new study from the Netherlands has demonstrated the effectiveness of the ketogenic diet in the treatment of children with refractory epilepsy. The trial aimed to evaluate the efficacy of ketogenic dietary treatment, and to search for child- or diet-related factors that can predict its effectiveness after 12 months follow-up. In addition, the team wished to determine the usefulness of read more

Predictors for medication adherence identified in youths with epilepsy

US researchers have identified several psychosocial predictors that can help to forecast whether or not youths with newly-diagnosed epilepsy will successfully adhere to treatment. The Cincinnati Children’s Hospital Medical Center aimed to find modifiable behavioural predictors of two-year antiepileptic drug (AED) adherence trajectories among young people with epilepsy, controlling for known demographic and medical factors. It is well established that read more

Generic lamotrigine shows equivalence to branded version in epilepsy trial

A new study has offered fresh confirmation of the equivalent performance that the generic version of lamotrigine, an antiepileptic drug (AED), can provide when compared to the original branded version. Led by the University of Maryland, the study aimed to test the pharmacokinetic performance of both versions in ‘generic-brittle’ patients with epilepsy – those who previously showed sensitivity when switching read more

Adverse event risk of levetiracetam confirmed by new study

A new review of existing clinical evidence has provided a clearer insight into the risk of adverse events associated with the antiepileptic drug (AED) levetiracetam. In total, 26 studies with 2,832 patients were included in the University of Perugia-led analysis, which appeared in the medical journal Seizure. The meta-analysis included all available double-blind, randomised placebo-controlled trials performed in any age, read more

Lidocaine ‘may be useful in treating status epilepticus’

A new systematic review of existing evidence has demonstrated the potential benefits of intravenous lidocaine as a means of controlling status epilepticus (SE) and refractory status epilepticus (RSE). For this new study, published in the medical journal Seizure, 13 studies involving 76 adult patients were assessed. The cohort experienced 82 episodes of SE/RSE, with patients receiving a number of different read more

Social anxiety ‘higher in epilepsy patients and their families’

Posted 20 Jul 2015 in Other treatments

Adults with epilepsy are more likely to experience social anxiety, with this impact also felt by their close family members, according to a new study. Carried out by Baskent University in Turkey, the research looked at anxiety, depression and social fear and avoidance levels in 48 adult patients with epilepsy and 48 first-degree cohabiting family members, compared to 43 controls. read more

Epilepsy and AEDs ‘can affect metabolism of certain patients’

A new study has highlighted the impact of epilepsy and antiepileptic drugs (AEDs) on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities. The Israeli study, published in the journal International Clinical Psychopharmacology, aimed to investigate how epilepsy and AEDs affect body mass index (BMI), fasting blood glucose (FBG) and total cholesterol of individuals in this demographic. read more

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