Our Research Portfolio

Every year we receive between 60 and 70 applications for research into all aspects of epilepsy, and our Scientific Advisory Committee has the task of deciding which of these should be supported. The quality grants that we have awarded in recent years are shown below (most recent first).

Sadly, our funding capacity each year is relatively limited, which means that promising applications have to be rejected. Your donation, no matter how large or small, will help us to fund as much excellent research as possible in the future!

 

GeneLoop: gene therapy activated by seizures to treat epilepsy

Grant winner 2017 ‘This project will investigate a flexible and self-regulated gene therapy approach to stop seizures. We will use seizures to stop seizures and this can potentially be a huge improvement for the treatment of intractable drug-resistant epilepsies. This fellowship will allow me to combine many years of study into the causes of network activity to develop a new read more

The role of inhibitory nerve cells in seizures

Grant winner 2017 ‘Surprisingly little remains known about the contribution of different cell types in the generation of seizures. While the conventional view is that seizure onset and maintenance are associated with failed inhibitory control of network excitability, some studies point that hyperactivity of interneurons may paradoxically play a role in the generation of pathological epileptiform discharges. Since many antiepileptic read more

Neurodevelopment after prenatal exposure to seizures (NAPES) study

Grant winner 2017 ‘Understanding whether transient maternal seizures during pregnancy are associated with poorer child neurodevelopment will aid treatment decisions for women with epilepsy and their doctors.’ Dr Rebecca Bromley (pictured) Grant type: Project grant Principal investigator: Dr Rebecca Bromley Institution: University of Manchester Amount: £149,963 Duration: 36 months Scientific title: Neurodevelopment after prenatal exposure to seizures (NAPES) study Background Children who are exposed to read more

The Incidence of Hospital Admissions with prolonged Seizures and Status Epilepticus in England 1990-2015

Grant winner 2017 ‘Very prolonged seizures (status epilepticus) can have devastating consequences and can result in death. It is critical to understand how recent changes in the treatment of seizures and epilepsy have impacted upon status epilepticus. Funding from ERUK will enable us to determine how common status epilepticus is in the UK, how that has changed over time and read more

Modulation of glial signalling as a novel therapy for absence epilepsy

Grant winner 2017 ‘Absence epilepsy is a childhood form of epilepsy, in which there are sudden and brief interruptions of consciousness. If these happen frequently enough they can interfere with learning and can lead to convulsions. We plan to investigate the role that glial cells play in this condition. We hypothesize that deficits in one particular form of glial cell read more

Recording brain activity using electrodes placed in the nose

Grant winner 2017 ‘Routine low-risk access to electrical activity in deep-seated brain areas will improve not only the diagnostic yield of EEGs, but also aid our understanding of seizure subtypes and neuronal networks involved in their generation.’ Dr Dora Lozadi (pictured) Grant type: Pilot grant Principal investigator: Dr Dora Lozsadi Institution: St George’s Hospital, London Amount: £30,000 Duration: 12 months Scientific title: Naso-ethmoidal EEG recording read more

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