Our Research Portfolio

Every year we receive between 60 and 70 applications for research into all aspects of epilepsy, and our Scientific Advisory Committee has the task of deciding which of these should be supported. The quality grants that we have awarded in recent years are shown below (most recent first).

Sadly, our funding capacity each year is relatively limited, which means that promising applications have to be rejected. Your donation, no matter how large or small, will help us to fund as much excellent research as possible in the future!

 

How do women with epilepsy take decisions about pregnancy?

About a third of the 456,000 people with epilepsy in the UK are women of childbearing age (16 to 45 years). Many of these women may become pregnant whilst taking anti-epileptic drugs. We know a great deal about the effect of these drugs on the mother’s seizures, and more and more about how both the drugs and the seizures affect read more

Looking for genes associated with idiopathic generalised epilepsy

Dr Andrew Makoff and his team at the Institute of Psychiatry in London will carry out a study on 469 DNA samples from patients with idiopathic generalised epilepsy (IGE) and their parents and some controls without epilepsy, to identify genes that influence susceptibility to epilepsy. IGE affects between 20 and 40% of people with epilepsy. It is an umbrella term read more

Storage capacity for an Epilepsy DNA Biobank

£9,600 (equipment grant) Professor Mark Rees, School of Medicine, University of Wales Swansea

Excessive neurotransmitter release during seizures – how and why?

Dr Michael Cousin of the University of Edinburgh will be looking at neurotransmitters, this time at the cellular processes that govern their release. Neurotransmitters are essential to normal brain activity. However during a seizure, too much neurotransmitter is released, leading to the spread of the seizure, and also to brain damage (since neurotransmitters are toxic in large amounts). Dr Cousin read more

Electrical activity in the brain just before a seizure starts

The area of the brain in which seizures start is called the seizure focus. In this area, the normal electrical signalling of the brain is not always totally controlled. If the excitability gets out of control, a seizure arises. The seizure focus therefore often has different electrical properties to those of the normal surrounding tissue. The area’s response to stimulation read more

The role of Ih in the entorhinal cortex during the latent period

£60,000 over 12 months (project grant) Dr Mala Shah, Department of Pharmacology, University College London; Dr Matthew Walker, Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London

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